Harmony Hub Health
Functional Medicine, Hormone Health and Weight Loss with Michele Postol, CRNP
Harmony Hub Health
Regenerative Medicine: The Future of Healing Is Already Here
What if your body isn’t breaking down so much as it’s missing the right signals to rebuild? We explore a practical roadmap for true repair—skin that thickens and brightens, joints that move with less pain, hair that regrows, and metabolism that finally wakes up. No fluff, just clear guidance on when to use PRP, exosomes, Wharton’s jelly, polynucleotides, and targeted peptides to match the state of your tissue and your goals.
We start with skin because that’s where most people first notice aging. Polynucleotides act like cellular CPR for dermal layers, improving collagen, elastin, and hydration, while plasma-based fibroblasting tightens lids, lines, and laxity without surgery. Pairing these with copper peptides and microneedling accelerates healing and texture shifts you can actually see. Then we move to the joints: PRP as your natural first responder for early arthritis and tendon pain, exosomes as the smart foreman that organizes repair when inflammation blocks progress, and Wharton’s jelly for those staring down surgery who need cushioning, scaffolding, and stronger, longer-lasting relief.
Regeneration doesn’t stop at procedures. Peptides function as software updates: CJC-1295 and ipamorelin boost growth hormone rhythms for tissue repair, sleep, and body composition; tesamorelin targets visceral fat to improve insulin sensitivity; MOTS-C upgrades mitochondrial energy; and the BPC157 plus TB500 “Wolverine” combo speeds tendon and ligament recovery. The throughline is precision—matching the right biologic to the right problem, stacking therapies thoughtfully, and letting biology do what it’s wired to do: heal.
Ready to trade symptom management for measurable repair? Subscribe, share this with someone who’s been told to “live with it,” and drop your top health goal so we can cover it next.
Find me at www.harmonyhubhealth.com
Email me at michele@harmonyhubhealth.com
Welcome to Harmony Hub Health, where my mission is to provide comprehensive, affordable, integrative care that addresses the root cause of health issues. At the Hub, the focus is on individual patient journeys. I strive to optimize health, vitality, and longevity, fostering a community where each person can thrive in body, mind, and spirit. Today I want to talk about regenerative medicine because the future of healing, it's already here. And yes, I know we started off talking about salmon sperm. If you've been anywhere near a skincare corner of the internet lately, you've probably heard whispers of anti-aging obsessions. One of them is that salmon sperm for the face. Yes, and I do have another podcast that is about the Tuscani. Um, and no, you don't need to clutch your pearls. But the truth is that these treatments use polynucleotides sourced from purified salmon DNA, not the fish itself, to repair skin at the cellular level. It helps to boost collagen, improves hydration, and restores that youthful, bouncy, I slept 10 hours and drink three liters of water type of glow. Um, that is polynucleotides as cellular CPR for your skin. And like I said, you can go listen to that Tuscani podcast, but it is a game changer. And the reason I like Tuscani is because um it has clinically significant 3% polynucleotide concentration. Many of the polynucleotides on the market, all of those formulas only have 1 to 2%. Some of them have a point percent, and they just say salmon sperm to make you think you're getting a full treatment. But lumisin from Tuscani is one of the more potent options that I have seen. So that means deeper cellular repair, faster, more visible rejuvenation, stronger collagen and elastin stimulation, um, increased hydration and tissue density, and just superior improvement in lines, texture, scarring, and laxity. So most polynucleotide products give your skin a little pep talk, but lumisin takes it to boot camp. All right. Um, and then also with regeneration, if we're going for the face, it's fibroblasting using the plasma pen for skin tightening. So if you want tightening, lifting, and wrinkle reduction without surgery, um, plasma pen, which is a controlled plasma energy treatment, it stimulates those fibroblasts. It doesn't smell the best, it smells like burning flesh, but it helps to make the tissue contract and it triggers new collagen and elastin. So for all of those that would love blephroplasty but don't want to have surgery, uh, plasma pen is a good alternative. Or if you want to treat the crow's feet and perioral lines, if you have a loose neck or jawline, even if you wanted to treat stretch marks or scars or creepy areas, um plasma pen is great. You can even pair that with lumin or exosomes to accelerate repair and enrich results. Um, but there is a lot of downtime with plasma pen. But what I love about regenerative medicine is I can do this head to toe. Um, and healing isn't only skin deep. So regenerative medicine is not just about youthful skin or pain-free knees. It's about repairing, restoring, and revitalizing head to toe. So if we go from head to toe, um looking at your scalp, even, you know, exosomes, PRP can help you grow hair. Um, it can help your skin with the polynucleotide, lumisin 3%, and all of the Tuscani cocktails. Um, you know, on the face, that's the plasma pen. You can do microneedling, and copper peptides are really good for skin, face, and hair. If you go to your neck and your chest, plasma pen is great for creepy skin. Polynucleotides or exosomes are great for thinning and damaged skin. And we can also target stretch marks as well. Um, but let's not forget about the insides as we're moving our way down to our neck. So internal cellular repair. These can be BPC157 or TB500, even the combination of both. So I actually gave that to somebody this week for their plantar fasciitis. They are injections, but this boss babe has to run a marathon in like three weeks. So I'm like, all right, I'm giving her the Wolverine is what it's actually called. BPC 157, TB500 injections. We need to regenerate. So we need tissue repair, we need to lower inflammation. We gotta get this girl running because she's taking no for um, she's not taking no for an answer. She's gonna be running whether or not she's healed or not. Um, and then speaking of running, if we're talking about joints and musculoskeletal, this is where regenerative medicine for me is so huge. And I did two treatments this week. So I haven't been talking about this much, but I'm really excited to talk about regenerative therapy. So for joint and pain regeneration, um this week I did Wharton's jelly, I did exosomes, and um, maybe it was last week I did PRP for, but that was more for hair. So regenerative medicine for pain has advanced far beyond steroid injections and surgery. Today we have biologic therapies that help the body repair rather than mask pain. And three of those most powerful options are the Wharton's jelly or the exosomes or the platelet-rich plasma. Each has a very unique purpose, um, a very unique strength, and they're ideal candidates. So your body's own repair kit is your platelet-rich plasma, also known as PRP. It's created from your own blood and it's concentrated down to isolate your platelets. These are the first responders of healing. So platelets release growth factors that repair tissue, reduce inflammation, and stimulate collagen. So it's really good for mild to moderate arthritis. It's good for tendinitis if you have tennis elbow, golfer's elbow, rotator cuff issues, if you have a partial tear or a strain or a sprain. Um, if you have early cartilage breakdown or just any post-injury inflammation, somebody with mild to moderate pain or has earlier stage joint degeneration or an active injury who still has good baseline healing capacity, those are the perfect person for PRP. It's all natural, it comes out of your own body, it can speed healing without surgery, and it's a great first step before you do advance to something like exosomes or or Wharton's jelly. Um, PRP works with what your body is still capable of doing. So when degeneration is very advanced, PRP may not be strong enough on its own. So think of PRP as repairing a road that's damaged, but you can still drive on it. And I do tell all of my patients that your PRP is only as good as the donor. So if you're on a lot of medications or maybe age or your health is not the best, then I would not pick PRP for you. What I might pick though are exosomes. These are advanced cell signaling for regeneration. So exosomes are tiny biointelligent messengers that are released by stem cells. Their job is to tell your cells how to heal faster, better, and more efficiently. They don't become new tissue, they just direct your tissue to regenerate by transferring growth factors, peptides, RNA, and cellular instructions. So exosomes are best for somebody with moderate degeneration, somebody with chronic inflammation, slow healing, or poor tissue quality. If you have autoimmune-driven joint breakdown, or if you tried PRP and you didn't get the best response for it. The ideal candidate is someone whose body needs smarter instructions for repair, especially if inflammation is blocking healing or the joint environment is kind of stuck. So a lot of people like exosomes because of the strong anti-inflammatory action. Um, it's faster healing than compared to platelet-rich plasma. And you can also combine it with PRP for that double signal therapy. Exosomes do not provide structural cushioning or actual building material, but they do send those signals. Um, they just don't replace lost tissue. So you want to think of exosomes as the architect and project manager that shows your body how to rebuild correctly. Um, then we have the Wharton's jelly, and this is the most complete regenerative option. So Wharton's jelly is a cellular-rich tissue that's derived from umbilical cord matrix. It's ethically donated, screened, FDA regulated. It contains um mesenchymal stem cells, growth factors, uh cytokines, hyaluronic acid, and structural scaffolding. Um, Wharton's jelly does what PRP and exosomes cannot. It provides structure, cushioning, and regenerative signaling. So this is best for moderate to severe arthritis. If you're close to bone-on-bone, if you've lost a lot of cartilage, if you have chronic pain with limited mobility, or just very advanced tissue degeneration. So the ideal candidate for this is someone who's kind of staring down the face of a joint replacement. Maybe they've tried injections without success, or you need more than just inflammation reduction. You need actual tissue rebuilding. Um, people love Warten's jelly because it does provide padding and shock absorption inside the joint. Typically, right after people already tell me they feel a little bit better. That happened twice this week. It does regenerate cartilage and connective tissue. It's the strongest option to delay or avoid joint surgery. Um, and results often last longer than PRP or any type of steroids. So it does have a higher cost. So that's one of the limitations. Um, it's not appropriate for active infection or certain autoimmune conditions without prepping the body first. So you want to think of the Wharton's jelly as delivering new construction materials and the architect and the builder, you know, the most complete repair approach. So I love to do consultations and try to see which one would be best for you. There's also ozone, um, the prolozone that you can inject into joints for pain and inflammatory control as well. So that is head down to at least knee and then the feet, tendons, um, you know, BPC157 TB500 is a great rehab stack. PRP and exosomes work well for plantar fasciitis, tears, or sprains. Um, if it can age, degenerate, wrinkle, tear, or inflame, there's likely a regenerative way to support it. And what I love about regenerative medicine is it's so different. Traditional care often manages symptoms. Regenerative medicine works with your biology to signal your cells to repair growth factors, exosomes, polynucleotides. It helps to rebuild collagen, elastin, and extracellular matrix. You can restore function by improving local blood flow, reducing inflammation, and normalizing cell signaling. You can extend the durability of results with healthier tissue, not just a temporary filler effect. I know I've also done podcasts on peptides, but if regenerative medicine is the future of healing, then peptides are the body's biochemical software update. They tell your cells how to repair, regenerate, how to burn fat, how to build collagen, and restore function without forcing the body or overriding its natural systems. Peptides are short chains of amino acids and they act as cell signaling molecules. And when you use them very strategically, there's so much you can do with them. You can support your mitochondrial function and your cellular energy like NAD, you can boost growth hormone naturally, you can enhance sleep and recovery, you can improve metabolism, you can even target visceral fat and reduce inflammation and just repair tissue. Um, CJC1295 and epimeralin is one of my favorite growth hormone optimization duos. This combination increases your body's own natural production of growth hormone, not through synthetic hormones, but by activating the hypothalamus and the pituitary. So growth hormone is one of the most important hormones for repair, recovery, metabolism, and aging. And CJC and epimerelin give you faster healing and tissue repair. It increases lean muscle and helps you lose fat. It gives you better sleep and recovery. It improves your skin elasticity and collagen. This is why this is so good for anti-aging. And it supports joint and ligament healing. So I love this peptide for men and women that are over 30, that are experiencing slow recovery, inflammation, weight gain, poor sleep, decreased muscle tone, or just the earlier signs of aging. In regenerative therapy stacks, CJC and ipamarelin are often used to accelerate repair after PRP. Exosomes are Warten's jelly. For belly fat and visceral fat peptides, I love tesamerelin. So this is a very unique superpower because it specifically reduces visceral fat. This is that dangerous fat around organs that drives inflammation, insulin resistance, cardiovascular disease, and accelerated aging. So originally FDA approved tesamerelin for HIV-associated fat accumulation, but tesamerelin has become a metabolism-focused regenerative peptide because of its ability to shrink visceral fat without sacrificing muscle. So the benefits of tesamerelin is that abdominal and visceral fat reduction. It does improve metabolic function and insulin sensitivity. It is great for sleep and to give you better energy and it preserves your lean muscle. So this peptide is for my patients with stubborn midsection fat, insulin resistance, metabolic dysfunction, or any type of inflammation-driven weight gain, especially peri and postmenopause men and women over 40. Okay. Next is the BPC157 and TB500. I've used this twice this week. This is for accelerated tissue tendon and injury repair. These two peptides are the injury repair power duo. The company I use actually calls it wolverine, and they're frequently used in regenerative medicine for tendinitis, muscle strains, joint degeneration, ligament tears, or post-surgery recovery. So BBC 157 works the cellular first aid. It heals the gut lining, connective tissue, and inflammatory injuries. And then TB500 enhances tissue regeneration, flexibility, and blood vessel growth into damaged areas. Together, they dramatically speed recovery and improve outcomes when combined with PRP or exosomes or Wharton's jelly as well. So you can use them for plantar fasciitis. I've actually seen people inject it close to their plantar fascia, but it can work systemically as well. One of my favorites that took forever for me to be able to source it is the MOTS C. This is the mitochondrial peptide for energy, fat burning, and longevity. So if you want a peptide that works at the cellular energy level, MOTS C, it is a mitochondrial peptide that's derived from mitochondrial DNA that improves how your body uses fuel. So the benefits is improved mitochondrial function and energy, exercise performance, increased fat burning and metabolic flexibility. It does support blood sugar regulation and reduces inflammation. So this is the one I pick for my patients with chronic fatigue, very slow metabolism, insulin resistance, inflammatory conditions, or anyone on a longevity or anti-aging program. MOTC wakes up tired cells. So the rest of your regenerative therapies can work much better. One of the newest ones that I just got for myself to try is the GHKCU or the copper binding peptide. This is the beauty and the brains and the healing peptide. So it's best known for skin and hair rejuvenation benefits, but it also supports tissue repair, collagen, and even cognitive health. So the benefits of the copper peptide is that it can increase collagen and elastin. It can reduce fine lines, texture, scars, and pigments. It can stimulate hair growth. It can speed wound healing and it protects your nerves and brain tissues. It's great to use with microneedling or after plasma pen to help with healing or for hair restoration. I love the skincare that I can compound that actually has, say, niacinamide and copper peptide, even estradiol. You can even throw some tretinoin in there. I can pretty much compound anything for skin right now. So it is absolutely amazing to watch the transformations. Okay, I'm gonna give full disclosure. Today's episode was originally just supposed to be about joint regenerative therapies because I had so much fun this week in injecting joints. But you know me, once I get excited, I cannot not share the whole picture. And regenerative medicine is one of those topics where it's impossible to stay in one lane. The truth is, what started in orthopedics for joint pain and injury repair has now expanded into skin, hair, metabolic health, hormones, gut, longevity, and full body healing. And that's what makes regenerative medicine so different from conventional medicine. Traditional medicine often says, oh, you're getting older, that's normal, or here's a medicine to mask the symptom, or we can manage it, but we can't fix it. Whereas regenerative medicine says, let's repair the tissue, let's restore function, let's get to the root cause so your body can heal itself. We're not just slapping a band-aid on pain or aging. We're literally stimulating the body to regenerate, rebuild, and biologically age younger. This is the future of medicine. Not managing decline, but reversing it. Not numbing symptoms, but regenerating what was damaged and not learn to live with it, but let's restore it so you can live better. The future is already here. Whether it's warten's jelly, rebuilding cartilage, or exosomes, repairing cellular communication, PRP for regenerating tissue, peptides to activate healing and metabolism, or polynucleotides to rebuild collagen and dermal structure. We are no longer guessing. I'm using science, biology, and your body's own intelligence to upgrade your health from the inside out. And that's why I couldn't just stop at joints today, because regenerative medicine is head-to-toe inside-out transformation. And most people have no idea this level of healing is even possible. If something you heard today made you think, wait, this could actually fix what I've been told is unfixable, then your next step is very simple. You can send me a message, email me at Michelle, that's M-I-C-H-E-L-E at harmonyhubhealth.com. You can text or call me at 410-575-4274, or come to my website at harmonyhubhealth.com. You could come and see me in person at Monarch Beauty and Spa in Manchester, Maryland. I would love to see you in person or virtual for a consultation. And I would love to talk about your symptoms, your goals, and which regenerative therapy is best to match your body, whether it's joint repair, skin rejuvenation, peptide therapy, or full body restoration. Because you don't have to just deal with it anymore. Your body can heal. It just needs the right tools. And I would love to show you what's possible. Okay, so this podcast is for educational and empowerment only. It's not your personal medical advice, your medical diagnosis, your treatment plan, or a permission slip to go inject yourself with something you found on the internet. Regenerative medicine is exciting, rapidly evolving, and yes, sometimes a little wild west. Therapies like PRP, exosomes, Wharton's jelly, peptides, ozone, and polynucleotides are not one size fits all, and results can vary from OMG, this changed my life, to my body said absolutely not. Do not stop your medications, ditch your current treatment plan, or fire your doctor because of something you heard here today. Talk with a qualified healthcare provider who actually knows your health history before trying anything new, especially if it comes in a syringe, a vial, or requires a numbing cream. So I'm here to educate, inspire, and show you what's possible, not to diagnose or treat you through a podcast. By listening, you do agree that you won't hold me or Harmony Hub Health liable for any choices you make based on this episode. I love ya, but I'm not climbing into your medical chart through your earbuds. Now that the legal fairy dust has been sprinkled, let's go regenerate some things.